Macroprolactin is an isoform of human prolactin (PRL) existing in low doses in plasma. In some patients, prolactine can be found in higher proportion, causing hyperprolactinaemia, in asyntomatic or symptomatic form. This abnormality has been also related to hypophysis adenome, doing necessary to count on reliable methods for its detection and measurement. The origin of this macro-
molecule, patogenia, hormonal regulation and natural history are not even clear, an antigenic complex IgG-PRL with reduced bioactivity is proposed. The Gold Standard for determination of macroprolactin is gel filtration chromatography, but its high costs and slowness restricts its use to research. Other methods for its detection already exist, the Polyethylene glycol precipitation is being
mostly accepted.
Jiménez R, B. ., Liberman G, C. ., Rojas G., P., & Romero O., C. . (2005). La macroprolactina, diagnóstico diferencial de la hiperprolactinemia. Revista Hospital Clínico Universidad De Chile, 16(3), pp. 179–84. https://doi.org/10.5354/2735-7996.2005.78665
